A Case of Pemphigus Vulgaris with Serum Autoantibodies Binding Blood Cell Antigen(s) on Immunofluorescence: A Case Report

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RESEARCH ARTICLE

A Case of Pemphigus Vulgaris with Serum Autoantibodies Binding Blood Cell Antigen(s) on Immunofluorescence: A Case Report

Alessandro Lanza1 , 2 Felice Femiano1 , 2 Giovanni Maria Gaeta1 Rossella Santoro2 Fernando Gombos1 , 2 Nicola Cirillo, * Open Modal , 1 , 2 , 3
Authors Info & Affiliations
The Open Dermatology Journal • 13 Oct 2007 • RESEARCH ARTICLE • DOI: 10.2174/1874372200701010010

Abstract

Patients with pemphigus vulgaris (PV) may develop autoimmunity against an array of non-desmoglein antigens, including keratinocyte acetylcholine receptors. The latter, along with yet unknown autoantigens, could participate to PV pathogenesis. Here, we report a case of PV developing autoimmunity against peripheral blood mononuclear cell (PBMC) antigens. The patient was poorly responsive to steroidal and immunosuppressive drugs. Although the role for this PBMC antigen has not been established, it could affect the behaviour of immune cells that regulate autoantibody production in PV. Deregulation of PBMC activity may therefore influence patient’s response to pharmacological therapy.