RESEARCH ARTICLE


Assessment of Vitamin D Status Among Cases with Pityriasis Alba



Wisam Majeed Kattoof1, *, Ahmed Abdulhussein Kawen2
1 AL-Mustansiriyah University/College of Medicine, FICMS Dermatology and Venerology, Baghdad, Iraq
2 University of ThiQar/College of Medicine, FICMS Dermatology and Venereology, Nasiriyah, Dhi Qar, Iraq


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© 2019 Kattoof and Kawen.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the New Baghdad. Sect.709/ street no.40/house no. 2, Baghdad, Iraq; Tel: 009647704355346;E-mail: wesam.majeed@uomustansiriyah.edu.iq


Abstract

Background:

Pityriasis alba, is a common benign skin disease occurring predominantly among children, often on their face. Clinically, the spots of pityriasis alba are off-white in color, round with poorly defined margins that bear scanty fine scales on it. No specific cause of pityriasis alba has been identified . In this disease, the number of melanocytes declines and melanosomes reduce within melanocytes. Vitamin D exerts its effect via the vitamin D receptor on melanocytes, if intracellular Ca2+ level decreases, this leads to high levels of reduced thioredoxin this, in turn, inhibit tyrosinase activity with the inhibition of melanin synthesis. In addition, the apoptotic activity of melanocytes reduces by the active form of vitamin D.

Aim:

The study aimed to assess the status of vitamin D for patients with pityriasis alba.

Materials and Methods:

44 patient diagnosed with pityriasis alba were enrolled and the second group of 44 controls was involved in our study. Serum levels of circulating 25 (OH) D were measured.

Results:

None of the cases had sufficient serum level; the level ranged between 8.1-27.3 ng/ml. The patients had lower circulating vitamin D levels than controls.

Conclusion:

Our findings in the present study are significant, but further studies with large samples are needed to correlate the extent and severity of pityriasis alba with vitamin D deficiency.

Keywords: Pityriasis alba, Melanocyte, Vitamin D, Serum level, Hypopigmentation, Pathogenesis.