RESEARCH ARTICLE
Carotid Intima-Media Thickness in Patients with Psoriasis
Hao Trong Nguyen1, *, Phuong Thi Doan Vo1, Nhi Thi Uyen Pham1, Thang Anh Bui2, Thao Phuong Nghiem2
Article Information
Identifiers and Pagination:
Year: 2021Volume: 15
First Page: 45
Last Page: 51
Publisher ID: TODJ-15-45
DOI: 10.2174/1874372202115010045
Article History:
Received Date: 12/1/2021Revision Received Date: 19/2/2021
Acceptance Date: 7/3/2021
Electronic publication date: 07/07/2021
Collection year: 2021
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Introduction:
Since the early 20th century, findings have demonstrated that psoriasis is frequently associated with atherosclerosis and cardiovascular diseases. The Carotid Intima-Media Thickness (CIMT) is a surrogate marker of atherosclerotic vascular disease.
Objective:
The aim of this study was to investigate the CIMT in patients with psoriasis and investigate its correlation with the clinical features.
Methods:
The present case-control study involved 70 patients with psoriasis who visited Ho Chi Minh City Hospital of Dermato-Venereology from September 2018 to April 2019 and 35 healthy subjects. Serum triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels were measured in both groups. Linear Doppler scanning was performed to evaluate the CIMT of the common, internal, and external carotid arteries and the presence of atherosclerotic plaques.
Results:
The mean CIMT value in psoriasis patients was significantly higher than that of controls [0.59 mm (0.53 - 0.71) vs. 0.54 mm (0.52 - 0.62), respectively, p = 0.036]. Multiple linear regression analysis revealed a significant correlation between the CIMT and age (p = 0.043) and CIMT and the Psoriasis Area and Severity Index (p < 0.0001). Moreover, the mean number of atherosclerotic plaques in psoriasis patients was significantly higher than that in controls [0.27 ± 0.68 vs. 0.03 ± 0.17, respectively, p = 0.035].
Conclusion:
Elderly patients with severe psoriasis should be evaluated carefully regarding CIMT and atherosclerotic plaques, as these signs are representative of increased cardiovascular risk.
