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REVIEW ARTICLE

A Clinical Review of Trichorrhexis Nodosa

Craig G Burkhart1 , 2 , * Open Modal Authors Info & Affiliations
The Open Dermatology Journal 26 Mar 2025 REVIEW ARTICLE DOI: 10.2174/0118743722373771250310062825

Abstract

Trichorrhexis nodosa is the most common form of hair breakage with a diagnostic splayed paint brush bristle appearance under light microscopy. It is classified into congenital and four acquired forms. Defects in the hair cuticle and hair keratin have recently been clarified better with more refined instrumentation. The congenital form can be seen in several childhood diseases and syndromes. There are four types of acquired TN that leave hair less protected from environmental irritants. The form with proximal damage in African Americans is by far the most frequent type. Treatment for trichorrhexis nodosa involves avoiding factors that contribute to hair breakage, such as minimizing heat styling and using gentle hair care products. The FDA may initiate sanctions on the use of formaldehyde and related chemicals presently used in hair straightening and keratin hair treatments. This would markedly alter the status quo in treatment for this condition.

Keywords: Trichorrhexis nodosa, Hair breakage, Formaldehyde, Hair straightening, Keratin hair treatments, Oil hair treatments.
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