Nanobiomaterials for Skin Tissue Engineering and Regenerative Medicine: From Mechanistic Understanding to Clinical Translation

Cell- and tissue-based therapy, as the main subfields of regenerative medicine, are critical interdisciplinary fields that are anticipated to constitute a significant portion of future medicine. To design and develop more effective cell- and tissue-based therapies for a diverse array of medical uses, particularly in the fields of skin tissue engineering and regenerative medicine, nanotechnology, biomaterial sciences, stem cell biology, and biomedical engineering, researchers are collaborating. Recently, the emergence of nanotechnology has revolutionized the landscape of skin tissue engineering and regenerative medicine by enabling the development of advanced nanobiomaterials and nanostructures with unparalleled functional and engineering properties. This narrative review aims to investigate the various applications of nanotechnology-based knowledge in cell- and tissue-based therapies for skin regeneration and dermatological practices. This study addresses the effects of nanotechnology-based approaches on biological responses, cell behavior, tissue integration, and the functional recovery of biological structures. Furthermore, the study highlights the promise of combining nanobiomaterials with cell engineering approaches to advance therapeutic outcomes in skin repair. According to a literature review, nanobiomaterials that are both effective and supportive can help produce structures resembling natural biological ones, alter the extracellular matrix, and direct stem cell fates. Nevertheless, the aim of the study is to encourage additional research and innovation, thereby establishing the foundation for the development of next-generation regenerative therapies for skin conditions and dermatology.