RESEARCH ARTICLE


A Topical Application Containing Sucralfate, Zinc Oxide and Ketoconazole Provides High Patient Satisfaction in the Treatment of Intertrigo



Craig G. Burkhart*, 1, Curtis Black2, Craig N. Burkhart3
1 University of Toledo College of Medicine, USA
2 University of Toledo College of Pharmacy, Toledo, Ohio, USA
3 Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA


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© 2009 Burkhart et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the University of Toledo School of Medicine, 5600 Monroe Street, Suite 106B, Sylvania, OH 43560, USA; Tel: 419-885-3403; Fax: 419-885-3401; E-mail:cgbakb@aol.com


Abstract

Intertrigo is a superficial inflammatory dermatitis involving juxtaposed skin surfaces subjected to friction, heat, moisture, and maceration. In response to encouraging reports of topical sucralfate’s effect on epithelialization of wounds as well as its bacteriostatic property, a clinical trial evaluating its possible role as a topical agent for intertrigo was initiated. For expected beneficial effects, zinc oxide and ketoconazole were added with sucralfate to the vehicle. The study was an open-label comparison designed to examine patient satisfaction with topical sucralfate vs the patients' prior therapies for their condition. At the conclusion of our pilot study, patients completed a survey questionnaire so that we could assess the value of this product in clinical usage. By all parameters queried, patient satisfaction was very high with this product for their condition. It is conjectured that such a formulation might be useful also for diaper rashes, diaper wipes, blisters, and open skin sores.