RESEARCH ARTICLE
Adherens Junctions, Desmosomes and Tight Junctions in Epidermal Barrier Function
Johanna M. Brandner1, §, Marek Haftek*, 2, §, Carien M. Niessen3, §
Article Information
Identifiers and Pagination:
Year: 2010Volume: 4
First Page: 14
Last Page: 20
Publisher ID: TODJ-4-14
DOI: 10.2174/1874372201004010014
Article History:
Received Date: 24/10/2009Revision Received Date: 06/12/2009
Acceptance Date: 10/12/2009
Electronic publication date: 23/4/2010
Collection year: 2010
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The skin is an indispensable barrier which protects the body from the uncontrolled loss of water and solutes as well as from chemical and physical assaults and the invasion of pathogens. In recent years several studies have suggested an important role of intercellular junctions for the barrier function of the epidermis. In this review we summarize our knowledge of the impact of adherens junctions, (corneo)-desmosomes and tight junctions on barrier function of the skin.