Development of an Ultraviolet A1 Light Emitting Diode-based Device for Phototherapy

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RESEARCH ARTICLE

Development of an Ultraviolet A1 Light Emitting Diode-based Device for Phototherapy

Shunko A. Inada, * Open Modal , 1 , 3 Satoshi Kamiyama1 Isamu Akasaki1 Kan Torii3 Takuya Furuhashi3 Hiroshi Amano2 Akimichi Morita3
Authors Info & Affiliations
The Open Dermatology Journal • 20 Mar 2012 • RESEARCH ARTICLE • DOI: 10.2174/1874372201206010013

Abstract

We developed a novel phototherapy device based on an ultraviolet light emitting diode (UV LED) with a peak wavelength of 365 nm and the full width at half maximum of 10 nm. The equipment comprised a 16 x 16 (50 cm x 50 cm) UV LED matrix. The system was designed to irradiate only the diseased part of the skin. To evaluate the characteristics of this device, we compared consumed power, irradiation intensity, uniformity of the irradiation intensity, rise time and stability of the irradiation intensity, and in vivo irradiation of mice between a conventional UVA1 (340-400 nm) phototherapy device and the UV LED device. The UVA1 LED device exhibited more desirable characteristics than the UVA1 lamp device, i.e., fewer thermal effects on in vitro and in vivo systems. Furthermore, to evaluate the efficacy of both light sources, cultured T cells were irradiated and the induction of apoptosis was analyzed. Both light sources efficiently induced apoptosis.

Keywords: Apoptosis, phototherapy, ultraviolet light emitting diode (UV LED).