RESEARCH ARTICLE


Persistent Effects of Adapalene Gel After Chemical Peeling with Glycolic Acid in Patients with Acne Vulgaris



Mikiko Uede1, *, Chikako Kaminaka1, 2, Nozomi Yonei3, Fukumi Furukawa1, Yuki Yamamoto1, 2
1 Department of Dermatology, Wakayama Medical University, Japan
2 Department of Cosmetic Dermatology and Photomedicine, Wakayama Medical University, Japan
3 Department of Dermatology, Public Naga Hospital, Japan

Article Information


Identifiers and Pagination:

Year: 2013
Volume: 7
First Page: 42
Last Page: 46
Publisher ID: TODJ-7-42
DOI: 10.2174/1874372220130815004

Article History:

Received Date: 24/06/2013
Revision Received Date: 5/08/2013
Acceptance Date: 6/08/2013
Electronic publication date: 20/9/2013
Collection year: 2013

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Creative Commons License
© Uede et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Dermatology, Wakayama Medical University, Postal code: 641-0012, 811-1, Kimiidera, Wakayama City, Wakayama Prefecture, Japan. Tel.: 073-441-0661; Fax: 073-441-1908; E-mail: kifubi@wakayama-med.ac.jp


Abstract

We investigated the usefulness of adapalene gel as maintenance therapy following chemical peeling with glycolic acid in patients with acne vulgaris. The study period was 14 weeks. The subjects were 23 patients with mild to moderate acne vulgaris (1 male, 22 females). After chemical peeling (CP) of the face was performed 3 times at 2-week intervals, adapalene was applied for 6 weeks using a randomized, double-blind half-side method. On the day of observation, dermatologists examined dermal findings, and measurement was conducted using instruments to analyze the physiological skin function. After the third session of CP was completed, both the inflammatory and non-inflammatory lesion counts significantly decreased. Subsequently, on the adapalene-treated side there were no change in the inflammatory and non-inflammatory lesion counts after the CP 3 times, but on placebo-treated side, there significant increase in the inflammatory and non inflammatory lesion counts. Concerning the results of measurement with instruments, the sebum capacity significantly decreased after the third session of CP. Subsequently, there were no changes after the 6-week application of adapalene or a placebo. These results suggest that post-CP adapalene application is an effective acne treatment method to improve efficacy and treatment adherence.

Keywords: Acne vulgaris(AV), chemical peeling(CP), adapalene.