RESEARCH ARTICLE


Diagnostic Tools for Borrelia Assessment in Humans



Serena Bonin*
Department of Medical Sciences, Unit of Dermatology, University of Trieste, Trieste, Italy


Article Metrics

CrossRef Citations:
0
Total Statistics:

Full-Text HTML Views: 3757
Abstract HTML Views: 1875
PDF Downloads: 648
ePub Downloads: 494
Total Views/Downloads: 6774
Unique Statistics:

Full-Text HTML Views: 1538
Abstract HTML Views: 927
PDF Downloads: 401
ePub Downloads: 298
Total Views/Downloads: 3164



Creative Commons License
© Serena Bonin; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Medical Sciences, Unit of Dermatology, Cattinara Hospital Strada di Fiume 447 34149, Trieste, Italy; Tel +39 040 3996266; Fax: +39 040 360605; Email: sbonin@units.it


Abstract

Although the etiological agent of Lyme disease has been known since 1980s, diagnosis of Lyme disease is still a controversial topic because of the wide range of clinical manifestations and the limited diagnostic tools available to assess Borrelia in humans.

The most used diagnostic tool for Lyme disease is currently serology, but also Polymerase chain reaction (PCR) and other methods are often used to prove Borrelia infection in different patients’ specimens. The present article deals with most of the diagnostic tools used in clinical practice for Lyme disease detection in human samples. Direct and indirect specific methods for Borrelia infection detection will be discussed.

The most recent peer reviewed publications as well as original results from our study and information provided by companies’ web sites have been analyzed to compile this review article.

Keywords: Borrelia, commercial kits, PCR, serologic tests, standardization.