Pilomatrixoma Mimicking a Pyogenic Granuloma Clinically: A Rare Case Report from Syria

Lina Al-Soufi1, Moatasem Hussein Al-janabi2, *, Boshra Wannous3, Rana Issa4, Zuheir Al-shehabi5
1 Department of Dermatology, National Hospital, Lattakia, Syria
2 Department of Pathology, Cancer Research Center, Tishreen University Hospital, Lattakia, Syria
3 Department of Dermatology, Tishreen University Hospital, Lattakia, Syria
4 Department of Pathology, Tishreen University Hospital, Lattakia, Syria
5 Department of Pathology, Director of Cancer Research Center, Tishreen University Hospital, Lattakia, Syria

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Creative Commons License
© 2022 Al-Soufi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Pathology, Cancer Research Center, Tishreen University Hospital, Lattakia, Syria; Email:



Pilomatrixoma is a benign skin tumor arising from the hair matrix cells. It is typically found in the head and neck region. However, few cases of pilomatrixoma that mimic a pyogenic granuloma have been reported. Clinicians should be aware of it because it may recurrence and transform into a malignant tumor.

Case Presentation:

We report a rare case of a 9-year-old boy who presented with an asymptomatic mass on the left cheek for 2 months. Clinically, it was diagnosed as a pyogenic granuloma. An excisional biopsy was performed and sent to the pathology department for histopathological study. Histological examination showed that it was a pilomatrixoma. The patient was discharged on the same day, without any complications.


Pilomatrixoma is often misdiagnosed clinically; therefore, the definitive diagnosis of skin tumors should be made after a histologic examination of the excisional mass. Surgical resection with wide margins was the optimal treatment for pilomatrixoma because local recurrence may occur.

Keywords: Pilomatrixoma, Calcifying epithelioma of Malherbe, Pyogenic granuloma, Hair matrix cells, Skin tumors, Neoplasm.