RESEARCH ARTICLE
Cytokines Levels in Children Affected by Atopic and Nonatopic Eczema
Giampaolo Ricci, Annalisa Patrizi2, Federica Bellini1, Elisabetta Calamelli1, Valeria Dell'Omo1, Barbara Bendandi1, Massimo Masi1
Article Information
Identifiers and Pagination:
Year: 2008Volume: 2
First Page: 18
Last Page: 21
Publisher ID: TODJ-2-18
DOI: 10.2174/1874372200802010018
Article History:
Received Date: 14/01/2008Revision Received Date: 21/01/2008
Acceptance Date: 23/01/2008
Electronic publication date: 6/2/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Patients with atopic eczema present higher serum levels of total IgE and different pattern of cytokines, compared to nonatopic eczematous patients. This study aimed to evaluate serum levels of IL-2, IL-4, IL-5, IL-10, IFNγ, TNFα in eczematous children in relation to atopic and nonatopic form. We enrolled 45 eczematous children and 12 controls. Total IgE and specific IgE against principal food and inhalant allergens were evaluated by UniCap1000 and levels of cytokines by Cytometric Bead Array System. The geometric means of levels of IL-4 were higher in eczematous patients than controls (P=0.036). Serum levels of IL-10 and IFNγ were higher in nonatopic eczematous children than in atopic eczematous patients and controls (P= 0.004, P= 0.003). Our data confirm that cytokines may play an important role in the pathogenesis of eczema: nonatopic eczema seems to be characterized by increased levels of IL-10 and IFNγ compared to atopic form.
