Lipid Rafts and Caveolae in the Terminal Differentiation of Epidermal Keratinocytes

Roelandt, Truus; Roseeuw, Diane; Giddelo, Christina; Hachem, Jean-Pierre

Lipid Rafts and Caveolae in the Terminal Differentiation of Epidermal Keratinocytes

Truus Roelandt¹, Diane Roseeuw¹, Christina Giddelo¹, Jean-Pierre Hachem^{*, 1, 2}

¹ Department of Dermatology, Universitair Ziekenhuis Brussel, Brussels, Belgium

² Centre Hospitalier Emile Mayrisch, Esch Sur Alzette, Luxembourg

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Identifiers and Pagination:

Year: 2009
Volume: 3
First Page: 146
Last Page: 150
Publisher ID: TODJ-3-146
DOI: 10.2174/1874372200903010146

Article History:

Received Date: 15/05/2009
Revision Received Date: 18/05/2009
Acceptance Date: 18/05/2009
Electronic publication date: 4/11/2009
Collection year: 2009

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© 2009 Roelandt et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

^* Address correspondence to this author at the Department of Dermatology, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, Brussels 1090, Belgium; E-mail:jeanpierre.hachem@uzbrussel.be

Lipid rafts are cholesterol and sphingolipid-enriched plasma membrane domains, Caveolae represent a subclass of lipid rafts and the chief structural proteins are caveolins (caveolin-1, -2 and –3). Caveolae formation plays a major role in epidermal barrier permeability, regulating lamellar body secretion and terminal differentiation. Disruption of the epidermal barrier leads to protease-activated receptor-2 activation and an increased intracellular calcium resulting in lamellar body secretion. Caveolin-1 is transported via the lamellar bodies to the plasma membrane, inserted into lipid rafts and initiates caveolae formation. The insertion of caveolin-1 serves as a “brake” in lamellar body secretion and signals terminal differentiation in order to restore an efficient epidermal barrier.

Keywords: Caveolae, lipid rafts, lamellar body secretion, terminal differentiation.

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RESEARCH ARTICLE

Lipid Rafts and Caveolae in the Terminal Differentiation of Epidermal Keratinocytes

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