Molecular Cryo-Electron Tomography of Skin

Norlen, Lars

Molecular Cryo-Electron Tomography of Skin

Lars Norlen^*

Department of Cellular and Molecular Biology, Karolinska Institute, Stockholm, Sweden

Article Information

Identifiers and Pagination:

Year: 2010
Volume: 4
First Page: 46
Last Page: 47
Publisher ID: TODJ-4-46
DOI: 10.2174/1874372201004010046

Article History:

Received Date: 15/09/2009
Revision Received Date: 05/11/2009
Acceptance Date: 10/12/2009
Electronic publication date: 23/4/2010
Collection year: 2010

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© 2010 Lars Norlen

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

^* Address correspondence to this author at the Department of Cellular and Molecular Biology (CMB), Karolinska Institute, Stockholm, Sweden; Tel: 00 46 (0)8 524 87658; E-mail: lars.norlen@ki.se

The three-dimensional structure of skin can be studied at near-native conditions at the molecular level with a new technique called molecular electron tomography of vitreous tissue sections (tissue TOVIS). Its usage is, however, still largely limited by a difficult sample handling procedure. Here we discuss some measures for the efficient application of tissue TOVIS to dermatological research.

Keywords: Skin barrier, cryo-electron microscopy of vitreous sections, CEMOVIS, cryo-electron tomography of vitreous sections, TOVIS.

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RESEARCH ARTICLE

Molecular Cryo-Electron Tomography of Skin

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